Abstract
An efficient and versatile synthesis of acylpolyamine spider toxins was developed based on the structural classification of the Nephila and Nephilengys spider toxins using the 2-nitrobenzenesulfonamide protecting group. The naturally occurring toxins 1-5 representing each structural type have been efficiently synthesized by this method in a high overall yield with few steps.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biogenic Polyamines / chemical synthesis*
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Chromatography, Liquid
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Heterocyclic Compounds / chemical synthesis
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Heterocyclic Compounds / chemistry
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Indicators and Reagents
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Mass Spectrometry
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Polyamines / chemical synthesis
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Polyamines / chemistry
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Spider Venoms / chemical synthesis*
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Spiders
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Structure-Activity Relationship
Substances
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Biogenic Polyamines
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Heterocyclic Compounds
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Indicators and Reagents
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JSTX-3
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Polyamines
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Spider Venoms