Interpretation of mucoadhesive properties of polymer gel preparations using a tensile strength method

J Pharm Pharmacol. 2001 Dec;53(12):1589-99. doi: 10.1211/0022357011778197.

Abstract

We have developed a new tensile strength method for assessing mucoadhesive properties of polymer gels utilising freshly excised porcine nasal mucosa and a texture analyser. In conjunction with this, we propose a method for interpreting the mucoadhesive properties that is based on reasoning about the locus of the failure of a mucoadhesive joint. This involves measuring the cohesiveness of the gel and the mucus layer, respectively, and comparing these results with those obtained from a mucoadhesion measurement. Linear polymers (sodium carboxymethylcellulose, poly(acrylic acid) and sodium hyaluronate) and a cross-linked polymer (poly(acrylic acid)) were used as model polymers in this study. It was shown that the withdrawal speed of the probe should be low, about 0.1 mm s(-1), and that a contact time of 2 min was sufficient. In the mucoadhesion measurements there was no dependence of the results on the contact time in the interval 2-20 min. The tensile work appeared to be more applicable than the fracture strength for interpreting mucoadhesive properties. Furthermore, it was concluded that the interpretation procedure offers a good basis by which to assess whether the measured tensile work reflects a cohesive failure of the gel or a true interaction of the gel with the mucus layer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Dosage Forms*
  • Gels
  • Mucous Membrane / metabolism*
  • Polymers
  • Tensile Strength*

Substances

  • Dosage Forms
  • Gels
  • Polymers