Biochemical and ultrastructural alterations in rat after hyperoxic treatment: effect of taurine and hypotaurine

Adv Exp Med Biol. 2000:483:149-56. doi: 10.1007/0-306-46838-7_15.

Abstract

The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected i.p.. Every 12 h either with 1 ml saline, 1 ml saline+30 mg hypotaurine or 1 ml saline+30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurine-treated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalase / metabolism*
  • Female
  • Glutathione Peroxidase / metabolism*
  • Glutathione Reductase / metabolism*
  • Hyperoxia / enzymology*
  • Muscle, Skeletal / drug effects
  • Muscle, Skeletal / enzymology*
  • Muscle, Skeletal / ultrastructure
  • Rats
  • Superoxide Dismutase / metabolism*
  • Taurine / administration & dosage
  • Taurine / analogs & derivatives*
  • Taurine / pharmacology*

Substances

  • Taurine
  • hypotaurine
  • Catalase
  • Glutathione Peroxidase
  • Superoxide Dismutase
  • Glutathione Reductase