Thymidylate synthase inhibition induces p53 dependent and independent cell death

Adv Exp Med Biol. 2000:486:303-6. doi: 10.1007/0-306-46843-3_59.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimetabolites, Antineoplastic / pharmacology
  • Apoptosis*
  • Caspase 3
  • Caspases / biosynthesis
  • Colonic Neoplasms
  • DNA Damage
  • Enzyme Inhibitors / pharmacology
  • Fas Ligand Protein
  • Fluorouracil / pharmacology
  • Folic Acid Antagonists / pharmacology
  • Glutamates / pharmacology
  • Guanine / analogs & derivatives
  • Guanine / pharmacology
  • Humans
  • Membrane Glycoproteins / biosynthesis
  • Pemetrexed
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Quinazolines / pharmacology
  • Thiophenes / pharmacology
  • Thymidylate Synthase / antagonists & inhibitors*
  • Tumor Cells, Cultured
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Antimetabolites, Antineoplastic
  • Enzyme Inhibitors
  • FASLG protein, human
  • Fas Ligand Protein
  • Folic Acid Antagonists
  • Glutamates
  • Membrane Glycoproteins
  • Proto-Oncogene Proteins c-bcl-2
  • Quinazolines
  • Thiophenes
  • Tumor Suppressor Protein p53
  • Pemetrexed
  • Guanine
  • Thymidylate Synthase
  • CASP3 protein, human
  • Caspase 3
  • Caspases
  • raltitrexed
  • nolatrexed
  • Fluorouracil