The role of deoxycytidine kinase in gemcitabine cytotoxicity

Adv Exp Med Biol. 2000:486:287-90. doi: 10.1007/0-306-46843-3_56.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antimetabolites, Antineoplastic / toxicity*
  • Antineoplastic Agents, Hormonal / pharmacology
  • Colorectal Neoplasms / enzymology
  • Colorectal Neoplasms / pathology
  • Deoxycytidine / analogs & derivatives*
  • Deoxycytidine / toxicity*
  • Deoxycytidine Kinase / genetics
  • Deoxycytidine Kinase / metabolism*
  • Dexamethasone / pharmacology
  • Enzyme Inhibitors / pharmacology
  • Female
  • Gemcitabine
  • Gene Expression
  • Glucocorticoids / pharmacology
  • HL-60 Cells
  • Humans
  • Protein Kinase C / antagonists & inhibitors
  • RNA, Messenger / metabolism
  • Ribonucleotide Reductases / antagonists & inhibitors*
  • Staurosporine / pharmacology
  • Tumor Cells, Cultured
  • U937 Cells

Substances

  • Antimetabolites, Antineoplastic
  • Antineoplastic Agents, Hormonal
  • Enzyme Inhibitors
  • Glucocorticoids
  • RNA, Messenger
  • Deoxycytidine
  • Dexamethasone
  • Ribonucleotide Reductases
  • Deoxycytidine Kinase
  • Protein Kinase C
  • Staurosporine
  • Gemcitabine