Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation

Bone Marrow Transplant. 2001 Oct;28(8):803-6. doi: 10.1038/sj.bmt.1703235.

Abstract

A sibling cord blood (CB) transplantation was performed in a boy with Wiskott-Aldrich syndrome. The CB (31 x 10(6) CD34(+) cells) derived from a newborn sister with neonatal alloimmune thrombocytopenia (NAIT) with 40,000 platelets/microl, caused by a maternal anti-HPA-5b and HLA-A2 antibody. Maternal serum did not inhibit clonogenicity after in vitro testing of megakaryopoiesis. Accordingly, this CB was accepted for sibling transplantation. The transplantation showed a good course with fast and sustained hematopoietic reconstitution (granulocytes >500/microl on day +16, platelets >50,000/microl on day +30). This case demonstrates a successful CB transplantation from a donor suffering from NAIT.

Publication types

  • Case Reports

MeSH terms

  • Antigens, CD / immunology*
  • Antigens, Human Platelet / immunology*
  • Bone Marrow / pathology
  • Child
  • Female
  • Fetal Blood / cytology*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Immunity, Maternally-Acquired
  • Infant, Newborn
  • Integrin alpha2
  • Integrins / immunology*
  • Isoantibodies / immunology*
  • Male
  • Megakaryocytes / pathology
  • Nuclear Family
  • Receptors, Collagen
  • Thrombocytopenia / blood
  • Thrombocytopenia / congenital*
  • Thrombocytopenia / immunology
  • Tissue Donors
  • Transplantation, Homologous* / immunology
  • Wiskott-Aldrich Syndrome / therapy*

Substances

  • 5b alloantigen, human
  • Antigens, CD
  • Antigens, Human Platelet
  • Integrin alpha2
  • Integrins
  • Isoantibodies
  • Receptors, Collagen