Arterial blood gas and pH analysis are performed during anesthesia or critical care medicine for (1) assessment of acid-base balance, (2) assessment of pulmonary oxygenation of arterial blood, and (3) assessment of alveolar ventilation by measurement of arterial blood PCO2. Total physiologic and alveolar dead spaces are evaluated by comparing the alveolar PCO2 with the mixed expired and mixed alveolar PCO2, respectively. This article provides a clinical approach and interpretation of arterial blood gas and pH analysis.