Inhaled nitric oxide in cardiology

Expert Opin Investig Drugs. 2001 Nov;10(11):1947-56. doi: 10.1517/13543784.10.11.1947.

Abstract

Inhaled nitric oxide (INO) allows selective pulmonary vasodilatation with rapidity of action. It is effective in the acute management of reversible pulmonary hypertension in cardiac medical and surgical patients and is also useful in assessing the pulmonary vasodilator capacity in patients with chronic pulmonary hypertension. This review will examine the role of INO in the management of cardiac patients, compared to alternatives where available. The use of INO in cardiac failure, post-operative cardiac patients, patients with congestive cardiac failure or congenital heart disease will also be reviewed. Newer alternatives with prolonged pulmonary activity and simpler administration are also discussed.

Publication types

  • Review

MeSH terms

  • Administration, Inhalation
  • Animals
  • Cardiac Surgical Procedures*
  • Endothelium, Vascular / pathology
  • Heart Failure / drug therapy
  • Humans
  • Hypertension, Pulmonary / drug therapy*
  • Hypertension, Pulmonary / physiopathology
  • Intraoperative Complications / drug therapy
  • Nitric Oxide / administration & dosage
  • Nitric Oxide / adverse effects
  • Nitric Oxide / physiology
  • Nitric Oxide / therapeutic use*
  • Postoperative Care
  • Vasodilator Agents / administration & dosage
  • Vasodilator Agents / therapeutic use

Substances

  • Vasodilator Agents
  • Nitric Oxide