Use of isotopes and LC-MS-ESI-TOF for mechanistic studies of tienilic acid metabolic activation

Adv Exp Med Biol. 2001:500:139-44. doi: 10.1007/978-1-4615-0667-6_17.
No abstract available

MeSH terms

  • Animals
  • Aryl Hydrocarbon Hydroxylases*
  • Chromatography, High Pressure Liquid
  • Clofibrate / metabolism
  • Cytochrome P-450 Enzyme System / metabolism*
  • Gas Chromatography-Mass Spectrometry
  • Isotope Labeling
  • Microsomes, Liver / metabolism
  • NADP / metabolism
  • Oxidation-Reduction
  • Oxygen / metabolism
  • Rats
  • Solvents
  • Steroid 16-alpha-Hydroxylase*
  • Steroid Hydroxylases / metabolism*
  • Ticrynafen / metabolism*
  • Uricosuric Agents / metabolism*
  • Water / metabolism
  • Yeasts

Substances

  • Solvents
  • Uricosuric Agents
  • Water
  • NADP
  • Cytochrome P-450 Enzyme System
  • Steroid Hydroxylases
  • Aryl Hydrocarbon Hydroxylases
  • CYP2C18 protein, human
  • Steroid 16-alpha-Hydroxylase
  • Ticrynafen
  • Clofibrate
  • Oxygen