Abstract
Mediastinal B-cell lymphoma is a locally highly aggressive tumor with a rather unique pattern of clinical, morphologic, imunologic, and genetic features distinct from other diffuse large B-cell lymphomas. Characterization of this disease has been hampered by the relatively low incidence of this lymphoma type. Although recent studies on larger numbers of cases have allowed new insights into biology and clinics of this lymphoma type, the histogenesis of mediastinal B-cell lymphoma is not yet fully understood. This review will list morphologic, immunlogic, and genetic properties of mediastinal B-cell lymphoma and discuss recent data regarding the biology of this lymphoma type.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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B-Lymphocytes / pathology
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Biomarkers, Tumor / analysis
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Chromosome Aberrations
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Chromosomes, Human, Pair 9 / genetics
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Chromosomes, Human, Pair 9 / ultrastructure
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Cytogenetics / methods
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Female
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Gene Amplification
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Gene Expression Regulation, Neoplastic
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Genes, Immunoglobulin
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Humans
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Janus Kinase 2
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Ki-1 Antigen / analysis
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Lymphoma, Large B-Cell, Diffuse / classification
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Lymphoma, Large B-Cell, Diffuse / genetics
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Lymphoma, Large B-Cell, Diffuse / immunology
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Lymphoma, Large B-Cell, Diffuse / mortality
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Lymphoma, Large B-Cell, Diffuse / pathology*
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Lymphoma, Non-Hodgkin / classification
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Lymphoma, Non-Hodgkin / genetics
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Lymphoma, Non-Hodgkin / immunology
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Lymphoma, Non-Hodgkin / mortality
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Lymphoma, Non-Hodgkin / pathology*
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Male
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Mediastinal Neoplasms / genetics
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Mediastinal Neoplasms / immunology
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Mediastinal Neoplasms / mortality
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Mediastinal Neoplasms / pathology*
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Neoplasm Proteins / genetics
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Neoplastic Stem Cells / pathology
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Protein-Tyrosine Kinases / genetics
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Proto-Oncogene Proteins*
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X Chromosome / genetics
Substances
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Biomarkers, Tumor
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Ki-1 Antigen
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Neoplasm Proteins
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Proto-Oncogene Proteins
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Protein-Tyrosine Kinases
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JAK2 protein, human
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Janus Kinase 2