Fluoroquinolone resistance among Streptococcus pneumoniae in Hong Kong linked to the Spanish 23F clone

Emerg Infect Dis. 2001 Sep-Oct;7(5):906-8. doi: 10.3201/eid0705.010526.

Abstract

Serotypes 6A/B, 19F, and 23F accounted for 73% of 140 mucosal isolates of Streptococcus pneumoniae from Hong Kong. In pulsed-field gel electrophoresis analysis, a group of related patterns was shared by 14 of 15 ciprofloxacin-resistant and 12 of 16 ciprofloxacin-susceptible isolates. These strains exhibited capsular switching and were highly similar to the Spanish 23F clone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents / pharmacology*
  • Child, Preschool
  • Ciprofloxacin / pharmacology*
  • Drug Resistance, Multiple, Bacterial*
  • Electrophoresis, Gel, Pulsed-Field
  • Erythromycin / pharmacology
  • Hong Kong / epidemiology
  • Humans
  • Infant
  • Microbial Sensitivity Tests
  • Middle Aged
  • Penicillins / pharmacology
  • Pneumonia, Pneumococcal / epidemiology*
  • Pneumonia, Pneumococcal / microbiology*
  • Serotyping
  • Spain / epidemiology
  • Streptococcus pneumoniae / classification
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Penicillins
  • Ciprofloxacin
  • Erythromycin