Synthesis of 3,4-disubstituted isoquinolines via palladium-catalyzed cross-coupling of o-(1-alkynyl)benzaldimines and organic halides

G Dai; R C Larock

doi:10.1021/ol0102085

Synthesis of 3,4-disubstituted isoquinolines via palladium-catalyzed cross-coupling of o-(1-alkynyl)benzaldimines and organic halides

Org Lett. 2001 Dec 13;3(25):4035-8. doi: 10.1021/ol0102085.

Authors

G Dai¹, R C Larock

Affiliation

¹ Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.

PMID: 11735578
DOI: 10.1021/ol0102085

Abstract

[reaction: see text] 3,4-Disubstituted isoquinolines have been prepared in good yields by the palladium-catalyzed cross-coupling of N-tert-butyl-o-(1-alkynyl)benzaldimines with aryl, allylic, and alkynyl halides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cyclization
Isoquinolines / chemical synthesis*
Isoquinolines / chemistry
Molecular Structure
Palladium / chemistry*

Substances

Isoquinolines
Palladium