Abstract
Hypotensive effects of aloeemodin, aloin A, elgonica dimer A and bisbenzopyran from Aloe barbadensis have been studied. Aloeemodin has emerged as a potent hypotensive agent in current pharmacological investigations and caused 26 %, 52 %, and 79 % falls in mean arterial blood pressure at the corresponding doses of 0.5, 1, and 3 mg/kg in rats. The paper also describes the absolute configuration of elgonica dimer A (1).
MeSH terms
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Aloe / chemistry*
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Animals
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Anthraquinones / chemistry
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Anthraquinones / isolation & purification
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Anthraquinones / therapeutic use*
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Antihypertensive Agents / therapeutic use*
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Blood Pressure / drug effects
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Dose-Response Relationship, Drug
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Emodin / analogs & derivatives*
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Emodin / chemistry
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Emodin / isolation & purification
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Emodin / pharmacology
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Emodin / therapeutic use*
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Glucosides / chemistry
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Glucosides / isolation & purification
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Glucosides / therapeutic use*
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Hypertension / drug therapy*
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Magnetic Resonance Spectroscopy
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Phytotherapy*
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Plant Leaves / chemistry
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Plant Preparations / therapeutic use*
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Plant Roots / chemistry
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Rats
Substances
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Anthraquinones
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Antihypertensive Agents
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Glucosides
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Plant Preparations
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elgonica dimer A
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aloe emodin anthrone
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Emodin
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alloin