Interferon therapy for orbital infiltration secondary to Erdheim-Chester disease

Am J Ophthalmol. 2001 Dec;132(6):945-7. doi: 10.1016/s0002-9394(01)01141-2.

Abstract

Purpose: To describe a 55-year-old male with Erdheim-Chester disease with bilateral orbital infiltration and visual loss who was successfully treated with interferon-alpha.

Methods: Interventional case report.

Results: The patient was treated with interferon-alpha and had an improvement in his clinical signs, including his visual acuity, after 4 weeks of interferon therapy.

Conclusion: Interferon-alpha can be effective in the treatment of orbital infiltration secondary to Erdheim-Chester disease.

Publication types

  • Case Reports

MeSH terms

  • Exophthalmos / diagnosis
  • Exophthalmos / drug therapy
  • Exophthalmos / etiology
  • Granuloma / complications
  • Granuloma / diagnosis
  • Granuloma / drug therapy*
  • Histiocytosis, Non-Langerhans-Cell / diagnosis
  • Histiocytosis, Non-Langerhans-Cell / drug therapy*
  • Histiocytosis, Non-Langerhans-Cell / etiology
  • Humans
  • Interferon-alpha / therapeutic use*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Orbital Diseases / diagnosis
  • Orbital Diseases / drug therapy*
  • Orbital Diseases / etiology
  • Osteosclerosis / diagnostic imaging
  • Radionuclide Imaging
  • Technetium Tc 99m Medronate
  • Visual Acuity
  • Xanthomatosis / complications
  • Xanthomatosis / diagnosis
  • Xanthomatosis / drug therapy*

Substances

  • Interferon-alpha
  • Technetium Tc 99m Medronate