Apolipoprotein E and age at onset of Alzheimer's disease in African American patients

Neurology. 2001 Nov 27;57(10):1923-5. doi: 10.1212/wnl.57.10.1923.

Abstract

The authors examined whether the APOE-epsilon4 allele is associated with an earlier age at onset of AD in 71 African American patients with probable AD. The authors found a linear dose effect in which each copy of the epsilon4 allele was associated with a 3.6-year earlier onset of AD, indicating a dose-dependent relationship between APOE-epsilon4 and age at onset of AD in African Americans.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alleles
  • Alzheimer Disease / genetics*
  • Apolipoprotein E4
  • Apolipoproteins E / genetics*
  • Black People / genetics*
  • Black or African American
  • Female
  • Gene Dosage
  • Genotype
  • Humans
  • Male
  • Middle Aged

Substances

  • Apolipoprotein E4
  • Apolipoproteins E