Endoplasmic reticulum in the heart, a forgotten organelle?

Mol Cell Biochem. 2001 Sep;225(1-):1-6. doi: 10.1023/a:1012209923231.

Abstract

Our hypothesis is that sarcoplasmic and endoplasmic reticulum Ca2+ stores may be functionally distinct compartments in cardiomyocytes. Sarcoplasmic reticulum Ca2+ store is responsible for control of excitation-contraction coupling whereas endoplasmic reticulum compartment may provide Ca2+ for housekeeping and transcriptional functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Calcium-Binding Proteins / genetics
  • Calcium-Binding Proteins / metabolism
  • Calreticulin
  • Endoplasmic Reticulum / metabolism*
  • Heart / growth & development
  • Humans
  • Intracellular Membranes / metabolism
  • Lectins / metabolism
  • Mice
  • Mice, Knockout
  • Myocardial Contraction
  • Myocardium / metabolism
  • Myocardium / ultrastructure*
  • Ribonucleoproteins / genetics
  • Ribonucleoproteins / metabolism
  • Sarcoplasmic Reticulum / metabolism
  • Transcription, Genetic

Substances

  • Calcium-Binding Proteins
  • Calreticulin
  • Lectins
  • Ribonucleoproteins
  • Calcium