Abstract
Vesicle budding requires recruitment of a coat, which must then be removed to allow fusion with the target compartment. In vitro assays have implicated Hsc70 and auxilin family members as key players in clathrin-coated vesicle uncoating. New in vivo studies now show that this is indeed the case and reveal additional functions of the Hsc70/auxilin complex.
MeSH terms
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Adaptor Proteins, Vesicular Transport
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Animals
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Biological Transport, Active
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Carrier Proteins / metabolism*
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Cell Membrane / chemistry
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Cell Membrane / metabolism
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Clathrin / genetics
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Clathrin / metabolism
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Clathrin-Coated Vesicles / metabolism*
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Endocytosis
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HSC70 Heat-Shock Proteins
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HSP70 Heat-Shock Proteins / metabolism*
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Membrane Proteins / metabolism*
Substances
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Adaptor Proteins, Vesicular Transport
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Carrier Proteins
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Clathrin
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HSC70 Heat-Shock Proteins
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HSP70 Heat-Shock Proteins
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Membrane Proteins