Hepatitis B virus nucleic acids circulating in the blood: distinct patterns in HBs carriers with hepatocellular carcinoma

Ann N Y Acad Sci. 2001 Sep:945:195-206. doi: 10.1111/j.1749-6632.2001.tb03886.x.

Abstract

Circulating nucleic acids in serum and plasma are common in a variety of disease conditions. Here, we focus (i) on our approach for the detection of various hepatitis B virus (HBV)-related nucleic acids in liver tissue and in serum, (ii) on the progression of the chronic HBV infection, (iii) on the relation of HBV-specific nucleic acids circulating in the blood of patients with hepatocellular carcinoma, and in general (iv) on the diagnostic potential of circulating HBV nucleic acids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carcinoma, Hepatocellular / blood*
  • Carrier State*
  • Disease Progression
  • Hepatitis B Surface Antigens / genetics*
  • Hepatitis B virus / genetics*
  • Humans
  • Liver Neoplasms / blood*
  • Molecular Sequence Data
  • Sequence Homology, Amino Acid
  • Trans-Activators / chemistry
  • Trans-Activators / genetics
  • Viral Regulatory and Accessory Proteins

Substances

  • Hepatitis B Surface Antigens
  • Trans-Activators
  • Viral Regulatory and Accessory Proteins
  • hepatitis B virus X protein