Abstract
Three genes, ced-2, ced-5, and ced-10, are required for both cell corpse engulfment and distal tip cell migration in C. elegans. Recently, a fourth gene, ced-12, has been identified that is required for these two processes. ced-12 encodes a novel, conserved adaptor molecule involved in the activation of Rho/Rac/CDC42-like GTPases.
MeSH terms
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Animals
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Apoptosis Regulatory Proteins
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Caenorhabditis elegans
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Caenorhabditis elegans Proteins*
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Carrier Proteins / physiology
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Cytoskeletal Proteins*
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Helminth Proteins / physiology*
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Membrane Proteins / physiology*
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Phagocytosis / physiology*
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Protein Kinases / physiology*
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Proto-Oncogene Proteins c-crk
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Proto-Oncogene Proteins*
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rac GTP-Binding Proteins*
Substances
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Apoptosis Regulatory Proteins
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CED-10 protein, C elegans
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CED-12 protein, C elegans
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CED-5 protein, C elegans
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Caenorhabditis elegans Proteins
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Carrier Proteins
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Cytoskeletal Proteins
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Helminth Proteins
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Membrane Proteins
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Proto-Oncogene Proteins
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Proto-Oncogene Proteins c-crk
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Protein Kinases
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rac GTP-Binding Proteins