Sensory adaptation in naive peripheral CD4 T cells

J Exp Med. 2001 Nov 5;194(9):1253-61. doi: 10.1084/jem.194.9.1253.

Abstract

T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligands control the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoid organs. Here we show that pMHC contact modulates the expression of CD5 by naive CD4 T cells in a process that requires the continued expression of p56(lck). Reduced CD5 levels in T cells deprived of pMHC contact are predictive of elevated Ca(2)+ responses to subsequent TCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contact may be important for regulating naive CD4 T cell responsiveness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological / immunology*
  • Animals
  • CD4-Positive T-Lymphocytes / immunology*
  • CD5 Antigens / biosynthesis
  • CD5 Antigens / immunology
  • H-2 Antigens / biosynthesis
  • H-2 Antigens / immunology
  • Haplotypes
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / biosynthesis
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / immunology
  • Major Histocompatibility Complex / immunology
  • Mice

Substances

  • CD5 Antigens
  • H-2 Antigens
  • Lymphocyte Specific Protein Tyrosine Kinase p56(lck)