Abstract
Reactive oxygen species (ROS) primarily arise from products of normal metabolic activities and are thought to be the etiology of many diseases. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was designed to be a functional mimic of the glutathione peroxidase that normally removes ROS. 2-TeCD exhibited highly catalytic efficiency and good water solubility. Antioxidant activity was studied by using ferrous sulfate/ascorbate-induced mitochondria damage model system. 2-TeCD protected the mitochondria against oxidative damage in a dose-dependent manner and exhibited also great antioxidant ability in comparison with 2-phenyl-1,2-benziososelenazol-3(2H)-one. The mimic may result in better clinical therapies for the treatment of ROS-mediated diseases.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antioxidants / chemistry*
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Antioxidants / metabolism
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Antioxidants / pharmacology*
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Azoles / pharmacology
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Cattle
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Cyclodextrins / chemistry*
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Cyclodextrins / metabolism
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Cyclodextrins / pharmacology*
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Dose-Response Relationship, Drug
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Glutathione Peroxidase / chemistry
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Glutathione Peroxidase / metabolism
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Isoindoles
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Magnetic Resonance Spectroscopy
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Mitochondria, Heart / drug effects
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Mitochondria, Heart / metabolism
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Molecular Structure
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Organometallic Compounds / chemistry*
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Organometallic Compounds / metabolism
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Organometallic Compounds / pharmacology*
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Organoselenium Compounds / pharmacology
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Oxidative Stress
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Reactive Oxygen Species / metabolism
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Solubility
Substances
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Antioxidants
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Azoles
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Cyclodextrins
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Isoindoles
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Organometallic Compounds
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Organoselenium Compounds
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Reactive Oxygen Species
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dicyclodextrinyl ditelluride
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ebselen
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Glutathione Peroxidase