A novel dicyclodextrinyl ditelluride compound with antioxidant activity

FEBS Lett. 2001 Nov 2;507(3):377-80. doi: 10.1016/s0014-5793(01)03011-3.

Abstract

Reactive oxygen species (ROS) primarily arise from products of normal metabolic activities and are thought to be the etiology of many diseases. A novel dicyclodextrinyl ditelluride (2-TeCD) compound was designed to be a functional mimic of the glutathione peroxidase that normally removes ROS. 2-TeCD exhibited highly catalytic efficiency and good water solubility. Antioxidant activity was studied by using ferrous sulfate/ascorbate-induced mitochondria damage model system. 2-TeCD protected the mitochondria against oxidative damage in a dose-dependent manner and exhibited also great antioxidant ability in comparison with 2-phenyl-1,2-benziososelenazol-3(2H)-one. The mimic may result in better clinical therapies for the treatment of ROS-mediated diseases.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry*
  • Antioxidants / metabolism
  • Antioxidants / pharmacology*
  • Azoles / pharmacology
  • Cattle
  • Cyclodextrins / chemistry*
  • Cyclodextrins / metabolism
  • Cyclodextrins / pharmacology*
  • Dose-Response Relationship, Drug
  • Glutathione Peroxidase / chemistry
  • Glutathione Peroxidase / metabolism
  • Isoindoles
  • Magnetic Resonance Spectroscopy
  • Mitochondria, Heart / drug effects
  • Mitochondria, Heart / metabolism
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Organometallic Compounds / metabolism
  • Organometallic Compounds / pharmacology*
  • Organoselenium Compounds / pharmacology
  • Oxidative Stress
  • Reactive Oxygen Species / metabolism
  • Solubility

Substances

  • Antioxidants
  • Azoles
  • Cyclodextrins
  • Isoindoles
  • Organometallic Compounds
  • Organoselenium Compounds
  • Reactive Oxygen Species
  • dicyclodextrinyl ditelluride
  • ebselen
  • Glutathione Peroxidase