Effects of peptides on generation of reactive oxygen species in subcellular fractions of Drosophila melanogaster

Bull Exp Biol Med. 2001 Jul;132(1):682-5. doi: 10.1023/a:1012588530643.

Abstract

We studied the effects of Epithalon (Ala-Glu-Asp-Gly) and Vilon (Lys-Glu) on free radical processes in highly inbred HA(+)line of Drosophila melanogaster. Vilon inhibited generation of reactive oxygen species in mitochondria, but stimulated this process in the cytosol. We found sex- and age-related differences in the generation of reactive oxygen species and cytosol antioxidant activity.

MeSH terms

  • Aging / physiology
  • Animals
  • Antioxidants / pharmacology
  • Cell Fractionation
  • Dipeptides / pharmacology*
  • Drosophila melanogaster / cytology
  • Drosophila melanogaster / drug effects*
  • Drosophila melanogaster / metabolism
  • Female
  • Larva / physiology
  • Male
  • Oligopeptides / pharmacology*
  • Reactive Oxygen Species / metabolism*

Substances

  • Antioxidants
  • Dipeptides
  • Oligopeptides
  • Reactive Oxygen Species
  • lysylglutamic acid
  • alanyl-glutamyl-aspartyl-glycine