A case of muscular hamartoma of the breast

Breast Cancer. 2001;8(3):243-5. doi: 10.1007/BF02967516.

Abstract

We describe a 74-year-old female presenting with a right breast mass. She had found the mass on self-examination. Physical examination revealed a 2.2 x 2.5 cm, firm, smooth, and mobile lump in the upper medial portion of the right breast. Mammography revealed a well marginated, oval-shaped, and isodense nodule. Calcification was not evident. On ultrasonography, the lesion was 17 x 18 x 9 mm and located 5 mm below the overlying skin. Excisional biopsy under local anesthesia was performed. The tumor was easily excised. Histopathologically, the lesion was composed of intersecting bundles of spindle-shaped smooth muscle cells, and involved peripheral ducts and fat tissue. Immunohistochemical staining showed positivity for alpha-smooth muscle actin (SMA), but was negative for S-100 protein, myoglobin, keratin, and vimentin. From these findings a muscular hamartoma of the breast, a rare subtype of hamartoma, was diagnosed.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Breast Diseases / diagnostic imaging
  • Breast Diseases / pathology*
  • Breast Diseases / surgery
  • Diagnosis, Differential
  • Female
  • Hamartoma / diagnostic imaging
  • Hamartoma / pathology*
  • Hamartoma / surgery
  • Humans
  • Immunohistochemistry
  • Mammography
  • Muscle, Smooth
  • Ultrasonography