Abstract
Platelet aggregation is initiated by receptor activation coupled to intracellular signaling leading to activation of integrin alphaIIbbeta3. Recent advances in the study of platelet receptors for collagen, von Willebrand factor, thrombin, and adenosine diphosphate are providing new insights into the mechanisms of platelet aggregation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Integrins / physiology
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Models, Biological
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Platelet Aggregation*
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Platelet Glycoprotein GPIb-IX Complex / physiology
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Receptors, Collagen
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Receptors, Purinergic P2 / physiology
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Receptors, Thrombin / physiology
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Signal Transduction
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Thrombin / physiology
Substances
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Integrins
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Platelet Glycoprotein GPIb-IX Complex
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Receptors, Collagen
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Receptors, Purinergic P2
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Receptors, Thrombin
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Thrombin