Nonactin biosynthesis: disruption of the polyketide synthase genes, nonKJ, in Streptomyces griseus leads to an overall 96 decrease in macrotetrolide production, yet a net increase in nonactin analogues which incorporate isobutyrate

J Am Chem Soc. 2001 Oct 24;123(42):10415-6. doi: 10.1021/ja005749o.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Butyrates / metabolism*
  • Isobutyrates
  • Macrolides / metabolism*
  • Multienzyme Complexes / antagonists & inhibitors
  • Multienzyme Complexes / genetics*
  • Stereoisomerism
  • Streptomyces griseus / enzymology
  • Streptomyces griseus / genetics*
  • Streptomyces griseus / metabolism

Substances

  • Anti-Bacterial Agents
  • Butyrates
  • Isobutyrates
  • Macrolides
  • Multienzyme Complexes
  • isobutyric acid
  • nonactin