Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones

I K Kostakis; N Pouli; P Marakos; E Mikros; A L Skaltsounis; S Leonce; G Atassi; P Renard

doi:10.1016/s0968-0896(01)00130-4

Synthesis, cytotoxic activity, NMR study and stereochemical effects of some new pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones

Bioorg Med Chem. 2001 Nov;9(11):2793-802. doi: 10.1016/s0968-0896(01)00130-4.

Authors

I K Kostakis¹, N Pouli, P Marakos, E Mikros, A L Skaltsounis, S Leonce, G Atassi, P Renard

Affiliation

¹ Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, 17345, Athens, Greece.

PMID: 11597459
DOI: 10.1016/s0968-0896(01)00130-4

Abstract

Some new substituted pyrano[3,2-b]thioxanthen-6-ones and pyrano[2,3-c]thioxanthen-7-ones were prepared and their cytotoxic activity was evaluated using acronycine as the reference compound. The conformation of the molecules was also investigated in an effort to correlate this parameter with the biological activity.

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Division / drug effects
Drug Screening Assays, Antitumor
Inhibitory Concentration 50
Ketones
Leukemia L1210 / pathology
Magnetic Resonance Spectroscopy
Mice
Molecular Conformation
Pyrans / chemistry
Pyrans / pharmacology
Structure-Activity Relationship
Thioxanthenes / chemistry*
Thioxanthenes / pharmacology*
Tumor Cells, Cultured / drug effects

Substances

Antineoplastic Agents
Ketones
Pyrans
Thioxanthenes