Abstract
Ganglion blockers increase the antinociceptive defense in anesthesiological support of cardiopulmonary bypass operations for mitral and aortic valve failure. Benzohexonium decreased total peripheral vascular resistance, increased cardiac and stroke indexes, and increased systolic potency of the heart. Ganglionar blocking was associated with an increase of systemic oxygen transport, arrhythmias developed rarely, blood concentrations of epinephrine, norepinephrine, ACTH, vasopressin, and leukinferon were lower.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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Adrenocorticotropic Hormone / blood
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Adult
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Aged
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Aortic Valve Insufficiency / surgery*
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Cardiopulmonary Bypass*
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Epinephrine / blood
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Female
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Ganglionic Blockers / administration & dosage
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Ganglionic Blockers / pharmacology*
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Hemodynamics / drug effects
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Hexamethonium Compounds / administration & dosage
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Hexamethonium Compounds / pharmacology*
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Humans
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Male
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Middle Aged
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Mitral Valve Insufficiency / surgery*
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Norepinephrine / blood
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Oxygen / metabolism
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Stroke Volume / drug effects
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Vascular Resistance / drug effects
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Vasopressins / blood
Substances
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Ganglionic Blockers
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Hexamethonium Compounds
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Vasopressins
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Adrenocorticotropic Hormone
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Oxygen
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benzohexonium
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Norepinephrine
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Epinephrine