Synthesis of the L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine

Biosci Biotechnol Biochem. 2001 Aug;65(8):1879-82. doi: 10.1271/bbb.65.1879.

Abstract

The L-enantiomer of 4'-C-ethynyl-2'-deoxycytidine (2) was synthesized, but did not show any activity against HIV-1 up to 100 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / chemical synthesis
  • Anti-HIV Agents / pharmacology
  • Cell Line
  • Coloring Agents
  • Deoxycytidine / analogs & derivatives
  • Deoxycytidine / chemical synthesis*
  • Deoxycytidine / pharmacology
  • HIV-1 / drug effects
  • Hydrogen-Ion Concentration*
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Spectrometry, Mass, Fast Atom Bombardment
  • Stereoisomerism
  • Tetrazolium Salts
  • Thiazoles

Substances

  • 4'-C-ethynyl-2'-deoxycytidine
  • Anti-HIV Agents
  • Coloring Agents
  • Indicators and Reagents
  • Tetrazolium Salts
  • Thiazoles
  • Deoxycytidine
  • thiazolyl blue