Abstract
A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that an association of neck dissection plus chemoradiotherapy can be useful in the event of unresectable advanced carcinomas.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / pathology
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Carcinoma, Squamous Cell / radiotherapy*
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Carcinoma, Squamous Cell / surgery
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Cisplatin / administration & dosage
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Disease-Free Survival
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Female
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Fluorouracil / administration & dosage
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Head and Neck Neoplasms / drug therapy*
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Head and Neck Neoplasms / mortality
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Head and Neck Neoplasms / pathology
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Head and Neck Neoplasms / radiotherapy*
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Head and Neck Neoplasms / surgery
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Humans
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Infusions, Intravenous
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Lymph Node Excision*
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Male
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Middle Aged
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Neck / surgery
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Neoplasm Staging
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Proportional Hazards Models