Dermatomyositis and sarcoid-like reaction associated with multiple myeloma treated effectively by high-dose chemotherapy and autologous peripheral blood stem cell transplantation

Bone Marrow Transplant. 2001 Jun;27(11):1215-7. doi: 10.1038/sj.bmt.1703048.

Abstract

We report the case of a 46-year-old male who developed dermatomyositis and a sarcoid-like reaction in association with testicular relapse of multiple myeloma. The myositis progressed despite chemotherapy directed at the underlying malignant disorder and immunosuppressive treatment. There was, however, a dramatic and sustained response to high-dose chemotherapy and autologous peripheral blood stem cell transplantation which resulted in resolution of the myopathy and partial resolution of the sarcoid-like reaction. This case report highlights the potential of autologous stem cell transplantation as treatment for para-neoplastic disorders associated with haematological malignancies.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Combined Modality Therapy
  • Dermatomyositis / diagnosis
  • Dermatomyositis / etiology
  • Dermatomyositis / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Male
  • Middle Aged
  • Multiple Myeloma / complications*
  • Multiple Myeloma / therapy
  • Recurrence
  • Sarcoidosis / diagnosis
  • Sarcoidosis / etiology
  • Sarcoidosis / therapy*
  • Testicular Neoplasms / therapy
  • Treatment Outcome