Selective, orally active MMP inhibitors with an aryl backbone

T E Barta; D P Becker; L J Bedell; G A De Crescenzo; J J McDonald; P Mehta; G E Munie; C I Villamil

doi:10.1016/s0960-894x(01)00487-5

Selective, orally active MMP inhibitors with an aryl backbone

Bioorg Med Chem Lett. 2001 Sep 17;11(18):2481-3. doi: 10.1016/s0960-894x(01)00487-5.

Authors

T E Barta¹, D P Becker, L J Bedell, G A De Crescenzo, J J McDonald, P Mehta, G E Munie, C I Villamil

Affiliation

¹ Pharmacia, Department of Medicinal Chemistry, 4901 Searle Parkway, Skokie, IL 60077, USA. barta@netmug.org

PMID: 11549451
DOI: 10.1016/s0960-894x(01)00487-5

Abstract

This letter describes SAR exploration and rat PK optimization of a series of novel, MMP-1 sparing aryl hydroxamate sulfonamides with activity against MMP-2 and MMP-13.

MeSH terms

Administration, Oral
Animals
Biological Availability
Drug Design
Matrix Metalloproteinase 13
Matrix Metalloproteinase Inhibitors*
Piperidines / chemistry*
Piperidines / pharmacology*
Protease Inhibitors / chemistry*
Protease Inhibitors / pharmacology*
Rats
Structure-Activity Relationship
Sulfhydryl Compounds / chemistry*
Sulfhydryl Compounds / pharmacology*

Substances

Matrix Metalloproteinase Inhibitors
Piperidines
Protease Inhibitors
Sulfhydryl Compounds
Matrix Metalloproteinase 13
Mmp13 protein, rat