[Disorders of blood rheology in Walker's carcinosarcoma-256 and in cyclophosphamide treatment of rats]

M B Plotnikov; M Iu Maslov; O I Aliev; A S Vasil'ev; E P Zueva; S G Krylova; N V Shilova

[Disorders of blood rheology in Walker's carcinosarcoma-256 and in cyclophosphamide treatment of rats]

Vopr Onkol. 2001;47(3):335-7.

[Article in Russian]

Authors

M B Plotnikov¹, M Iu Maslov, O I Aliev, A S Vasil'ev, E P Zueva, S G Krylova, N V Shilova

Affiliation

¹ Research Institute of Pharmacology, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.

PMID: 11544834

Abstract

Tumor process development in rats inoculated with cellular suspension of transplantable Walker's carcinosarcoma-256 involved enhanced thickening of blood on day 7. Treatment with 20 mg/kg cyclophosphamide, thrice a day, every other day, retarded tumor process and brought hemorheologic indices further down, at the same time. Similar treatment of intact rats with cyclophosphamide caused hemorheologic disorders too.

Publication types

English Abstract

MeSH terms

Animals
Antineoplastic Agents, Alkylating / administration & dosage
Antineoplastic Agents, Alkylating / adverse effects
Antineoplastic Agents, Alkylating / pharmacology*
Carcinoma 256, Walker / blood*
Carcinoma 256, Walker / drug therapy*
Cyclophosphamide / administration & dosage
Cyclophosphamide / adverse effects
Cyclophosphamide / pharmacology*
Hemorheology / drug effects*
Male
Rats
Rats, Wistar

Substances

Antineoplastic Agents, Alkylating
Cyclophosphamide