Stochastic feedback and the regulation of biological rhythms

Europhys Lett. 1998 Aug 15;43(4):363-8. doi: 10.1209/epl/i1998-00366-3.

Abstract

We propose a general approach to the question of how biological rhythms spontaneously self-regulate, based on the concept of "stochastic feedback". We illustrate this approach by considering at a coarse-grained level the neuroautonomic regulation of the heart rate. The model generates complex dynamics and successfully acounts for key characteristics of cardiac variability, including the l/f power spectrum, the functional form and scaling of the distribution of variations, and correlations in the Fourier phases indicating nonlinear dynamics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Circadian Rhythm / physiology*
  • Fractals
  • Heart Rate / physiology*
  • Homeostasis / physiology*
  • Humans
  • Mathematics
  • Models, Cardiovascular*
  • Nonlinear Dynamics*
  • Stochastic Processes*