Abstract
Experiments were conducted to determine the effects of physiologically elevated corticosterone on the activation of macrophages and T cells. These studies find that the elevation of corticosterone does not affect the expression of membrane receptors on macrophages and does not affect the activation of macrophages to produce cytokines. In contrast, elevated corticosterone levels correlate with enhanced T cell proliferation to both mitogens and superantigens.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Corticosterone / metabolism*
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Corticosterone / physiology
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Cytokines / biosynthesis
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Exotoxins / pharmacology*
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Immobilization / adverse effects
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Lipopolysaccharides / pharmacology*
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Macrophages / drug effects
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Macrophages / immunology
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Macrophages / metabolism*
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Mice
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Protein Kinase C / metabolism
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Protein Kinase C / physiology
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Staphylococcus
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Stress, Physiological / etiology
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Stress, Physiological / immunology
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Stress, Physiological / physiopathology
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
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Tumor Necrosis Factor-alpha / biosynthesis
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Tumor Necrosis Factor-alpha / immunology
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Tumor Necrosis Factor-alpha / metabolism
Substances
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Cytokines
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Exotoxins
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Lipopolysaccharides
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Tumor Necrosis Factor-alpha
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Protein Kinase C
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Corticosterone