HIV-1 integrase inhibitory phenylpropanoid glycosides from Clerodendron trichotomum

Arch Pharm Res. 2001 Aug;24(4):286-91. doi: 10.1007/BF02975093.

Abstract

Seven phenylpropanoid glycosides named acteoside (1), acteoside isomer (2), leucosceptoside A (3), plantainoside C (4), jionoside D (5), martynoside (6), and isomartynoside (7) were isolated from Clerodendron trichotomum. Compounds 1 and 2 showed potent inhibitory activities against HIV-1 integrase with IC50 values of 7.8 +/- 3.6 and 13.7 +/- 6.0 microM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Disaccharides / pharmacology*
  • Guaiacol / analogs & derivatives*
  • Guaiacol / pharmacology
  • HIV Integrase Inhibitors / pharmacology*
  • HIV-1 / enzymology*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Oligonucleotides / pharmacology
  • Plant Extracts / analysis
  • Plant Extracts / pharmacology
  • Plants, Medicinal / chemistry*
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Disaccharides
  • HIV Integrase Inhibitors
  • Oligonucleotides
  • Plant Extracts
  • Guaiacol