REST acts through multiple deacetylase complexes

Neuron. 2001 Aug 16;31(3):339-40. doi: 10.1016/s0896-6273(01)00386-5.

Abstract

The RE1 binding silencer protein REST represses neuronal-specific gene expression in nonneuronal cell types. In this issue of Neuron, Ballas et al. show that REST inhibits gene expression via the recruitment of multiple histone deacetylase complexes.

Publication types

  • Comment
  • Review

MeSH terms

  • Amidohydrolases / metabolism*
  • Animals
  • DNA-Binding Proteins / metabolism
  • Gene Silencing
  • Neurons / physiology*
  • Promoter Regions, Genetic
  • Repressor Proteins / metabolism*
  • Spinal Cord / physiology
  • Transcription Factors / metabolism*
  • Transcription, Genetic
  • Zinc Fingers

Substances

  • DNA-Binding Proteins
  • RE1-silencing transcription factor
  • Repressor Proteins
  • Transcription Factors
  • Amidohydrolases