In peritoneal dialysis patients, polyglucose dialysis solution (PG-DS) influences serum levels of sodium, amylase, and lipase, and of iron parameters. We aimed to examine, in the blood or serum of continuous ambulatory peritoneal dialysis (CAPD) patients treated with PG-DS, changes in the concentrations of Na+, K+, Ca++, total Ca, phosphorus, urea nitrogen, creatinine, uric acid, total protein, albumin, and intact parathyroid hormone (iPTH); in lipid profile [total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, HDL:total cholesterol ratio]; and in acid-base status. We started studies in 14 CAPD patients in whom 7.5% PG-DS was applied for the overnight 2-L exchange (duration: about 10 hours). Determinations of blood chemistry were carried out at 1.6 +/- 0.8 months before the introduction of PG-DS (period I, n = 14); after 1.2 +/- 0.6 months (period II, n = 14), 4.4 +/- 0.8 months (period III, n = 11), and 8.8 +/- 2.4 months (period IV, n = 9) of PG-DS administration; and 2.0 +/- 0.6 months after PG-DS discontinuation (period V, n = 11). The most pronounced (significant) differences in the examined parameters were seen between periods I and III or periods I and IV for Na+ (140 +/- 3 mmol/L vs 136 +/- 4 mmol/L), K+ (4.2 +/- 0.6 mmol/L vs 4.8 +/- 0.6 mmol/L), total Ca (9.4 +/- 1.1 mg/dL vs 10.5 +/- 1.3 mg/dL), urea nitrogen (61.3 +/- 25.9 mg/dL vs 79.4 +/- 20.9 mg/dL), creatinine (10.7 +/- 2.6 mg/dL vs 12.8 +/- 4.3 mg/dL), uric acid (4.8 +/- 2.3 mg/dL vs 7.1 +/- 1.7 mg/dL), and total protein (61.7 +/- 10.8 g/L vs 70.5 +/- 8.0 g/L). Serum lipid levels were stable during PG-DS administration, but they increased after discontinuation of the PG-DS. Other studied parameters usually returned to pre-treatment values after PG-DS discontinuation. All patients were in good clinical status during the study. The changes in blood chemistry did not cause clinical intervention. Our results indicate that PG-DS influences blood chemistry. The observed differences need to be clinically analyzed.