OR-1--a mixture of esters of glyceric acid produced by Penicillium funiculosum and its antitrypsin activity

Folia Microbiol (Praha). 2001;46(1):21-3. doi: 10.1007/BF02825878.

Abstract

A mixture of related metabolites (denoted OR-1) was isolated from the fermentation broth of Penicillium funiculosum together with mitorubrinic acid. Structurally OR-1 is glyceric acid esterified with C14-C18 fatty acids. Steady-state studies revealed that OR-1 behaved like an uncompetitive trypsin inhibitor with Ki 17.6 mumol/L.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzoates / metabolism
  • Culture Media
  • Esters / metabolism
  • Fermentation
  • Glyceric Acids / chemistry
  • Glyceric Acids / metabolism*
  • Penicillium / growth & development
  • Penicillium / metabolism*
  • Plant Proteins / chemistry
  • Plant Proteins / metabolism*
  • Trypsin Inhibitors
  • alpha-Amylases / antagonists & inhibitors

Substances

  • Benzoates
  • Culture Media
  • Esters
  • Glyceric Acids
  • OR-1 metabolite
  • Plant Proteins
  • Trypsin Inhibitors
  • mitorubrinic acid
  • glyceric acid
  • alpha-Amylases