Case report of pallido-pyramidal disease with supplementary motor area involvement

P F Pradat; C Dupel-Pottier; L Lacomblez; F Salachas; V Meininger; L Lacomblez; L Spelle; I Bonnaud; M J Ribeiro; P Remy; Y Samson

doi:10.1002/mds.1126

Case report of pallido-pyramidal disease with supplementary motor area involvement

Mov Disord. 2001 Jul;16(4):762-4. doi: 10.1002/mds.1126.

Authors

P F Pradat¹, C Dupel-Pottier, L Lacomblez, F Salachas, V Meininger, L Lacomblez, L Spelle, I Bonnaud, M J Ribeiro, P Remy, Y Samson

Affiliation

¹ Fédération de Neurologie Mazarin, Hôpital de la Pitié-Salpétrière, Paris, France.

PMID: 11481707
DOI: 10.1002/mds.1126

Abstract

An C-flumazenil positron emission tomography (PET) study in a patient with pallido-pyramidal disease revealed a marked decrease in benzodiazepine-receptor density in the precentral gyrus cortex and the mesial frontal cortex. We suggest that, in addition to dysfunction of basal ganglia-dependent systems, degeneration of the supplementary motor area could also be involved in the patient's bradykinesia.

Publication types

Case Reports

MeSH terms

Adult
Basal Ganglia Diseases / diagnostic imaging*
Basal Ganglia Diseases / genetics
Brain Mapping
Consanguinity
Dominance, Cerebral / physiology
Flumazenil
Frontal Lobe / diagnostic imaging
Globus Pallidus / diagnostic imaging*
Humans
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Male
Motor Cortex / diagnostic imaging*
Neurodegenerative Diseases / diagnostic imaging*
Neurodegenerative Diseases / genetics
Pyramidal Tracts / diagnostic imaging*
Receptors, GABA-A / metabolism
Tomography, Emission-Computed*

Substances

Receptors, GABA-A
Flumazenil