Abstract
Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Apoptosis
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Caenorhabditis elegans Proteins*
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Calcium-Binding Proteins / biosynthesis*
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Calcium-Binding Proteins / chemistry
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Calcium-Binding Proteins / genetics*
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Caspases / chemistry
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Chromosomes, Human, Pair 2
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Cloning, Molecular
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DNA, Complementary / metabolism
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Electrophoresis, Polyacrylamide Gel
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Helminth Proteins / genetics*
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Humans
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Models, Genetic
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Molecular Sequence Data
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NF-kappa B / metabolism
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Nucleic Acid Hybridization
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Plasmids / metabolism
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Precipitin Tests
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Protein Isoforms
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Protein Structure, Tertiary
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RNA, Messenger / metabolism
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Homology, Amino Acid
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Tissue Distribution
Substances
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Apoptosis Regulatory Proteins
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CARD Signaling Adaptor Proteins
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Caenorhabditis elegans Proteins
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Calcium-Binding Proteins
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Ced-4 protein, C elegans
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DNA, Complementary
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Helminth Proteins
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NF-kappa B
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NLRC4 protein, human
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Protein Isoforms
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RNA, Messenger
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Caspases
Associated data
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GENBANK/AY027787
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GENBANK/AY027788
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GENBANK/AY027789
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GENBANK/AY027790