Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error

Am J Epidemiol. 2001 Jul 15;154(2):174-9. doi: 10.1093/aje/154.2.174.

Abstract

The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement error. This procedure assumes the availability of data from a reliability study of the biomarker. A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker.

Publication types

  • Validation Study

MeSH terms

  • Analysis of Variance
  • Bias*
  • Biomarkers / blood
  • Confidence Intervals*
  • Data Interpretation, Statistical*
  • Female
  • Free Radicals / blood
  • Humans
  • Male
  • ROC Curve*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Biomarkers
  • Free Radicals
  • Thiobarbituric Acid Reactive Substances