Two new cytotoxic and virucidal trisulfated triterpene glycosides from the Antarctic sea cucumber Staurocucumis liouvillei

J Nat Prod. 2001 Jun;64(6):732-6. doi: 10.1021/np000584i.

Abstract

Two new trisulfated triterpene glycosides, liouvillosides A (1) and B (2), have been isolated from the Antarctic sea cucumber Staurocucumis liouvillei. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Liouvillosides A (1) and B (2) are two new examples of a small number of trisulfated triterpene glycosides from sea cucumbers belonging to the family Cucumariidae. Both glycosides were found to be virucidal against herpes simplex virus type 1 (HSV-1) at concentrations below 10 microg/mL.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology*
  • Antiviral Agents / chemistry*
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Carbohydrate Conformation
  • Chlorocebus aethiops
  • Drug Screening Assays, Antitumor
  • Herpesvirus 1, Human / drug effects
  • Hydrolysis
  • Magnetic Resonance Spectroscopy
  • Methylation
  • Microbial Sensitivity Tests
  • Oligosaccharides / chemistry
  • Oligosaccharides / isolation & purification*
  • Sea Cucumbers / chemistry*
  • Spectrometry, Mass, Fast Atom Bombardment
  • Triterpenes / chemistry*
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*
  • Vero Cells

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Oligosaccharides
  • Triterpenes
  • liouvilloside A
  • liouvilloside B