Behavioral-independent features of complex heartbeat dynamics

Phys Rev Lett. 2001 Jun 25;86(26 Pt 1):6026-9. doi: 10.1103/PhysRevLett.86.6026.

Abstract

We test whether the complexity of the cardiac interbeat interval time series is simply a consequence of the wide range of scales characterizing human behavior, especially physical activity, by analyzing data taken from healthy adult subjects under three conditions with controls: (i) a "constant routine" protocol where physical activity and postural changes are kept to a minimum, (ii) sympathetic blockade, and (iii) parasympathetic blockade. We find that when fluctuations in physical activity and other behavioral modifiers are minimized, a remarkable level of complexity of heartbeat dynamics remains, while for neuroautonomic blockade the multifractal complexity decreases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Activities of Daily Living
  • Adrenergic beta-Antagonists / pharmacology
  • Adult
  • Atropine / pharmacology
  • Female
  • Fractals
  • Heart / drug effects
  • Heart / innervation
  • Heart / physiology*
  • Humans
  • Male
  • Metoprolol / pharmacology
  • Parasympathetic Nervous System / drug effects
  • Parasympathetic Nervous System / physiology
  • Parasympatholytics / pharmacology
  • Sympathetic Nervous System / drug effects
  • Sympathetic Nervous System / physiology

Substances

  • Adrenergic beta-Antagonists
  • Parasympatholytics
  • Atropine
  • Metoprolol