Abstract
We describe the design, synthesis and cell translocation capacity of a peptide derived from the third alpha-helix of the homeodomain of Antennapedia. The new sequence appears to be an efficient and nontoxic means to deliver a covalently linked peptide cargo into cells.
MeSH terms
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Antennapedia Homeodomain Protein
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Drug Carriers
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Drug Delivery Systems
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Drug Design
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Homeodomain Proteins / chemical synthesis*
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Homeodomain Proteins / chemistry
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Homeodomain Proteins / metabolism
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Humans
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Nuclear Proteins*
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Peptides / chemical synthesis
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Peptides / chemistry
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Peptides / metabolism
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Transcription Factors*
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Tumor Cells, Cultured
Substances
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Antennapedia Homeodomain Protein
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Drug Carriers
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Homeodomain Proteins
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Nuclear Proteins
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Peptides
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Transcription Factors