[Involvement of the IGF system in the pathogenesis of adrenocortical tumors]

C Gicquel; N Boulle; A Logié; N Bourcigaux; V Gaston; Y Le Bouc

[Involvement of the IGF system in the pathogenesis of adrenocortical tumors]

Ann Endocrinol (Paris). 2001 Apr;62(2):189-92.

[Article in French]

Authors

C Gicquel¹, N Boulle, A Logié, N Bourcigaux, V Gaston, Y Le Bouc

Affiliation

¹ Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, 75012 Paris.

PMID: 11353893

Abstract

Adrenocortical carcinoma remains a challenge for the therapeutist; prognosis is ominous. Various abnormalities playing a pathogenetic role have been recently described in adrenocortical tumors. Among them, dysregulation of the IGF system and imprinting mistakes at the 11p15 locus play a determining role in malignant transformation of adrenocortical cells. These markers of the malignant phenotype might markedly improve our diagnosis and prognosis abilities.

Publication types

English Abstract
Review

MeSH terms

Adrenal Cortex Neoplasms / diagnosis
Adrenal Cortex Neoplasms / genetics*
Adrenal Cortex Neoplasms / physiopathology
Animals
Cell Transformation, Neoplastic / genetics
Chromosomes, Human, Pair 11
Humans
Insulin-Like Growth Factor Binding Proteins / genetics
Insulin-Like Growth Factor I / genetics
Insulin-Like Growth Factor II / genetics
Mutation
Somatomedins / genetics*
Somatomedins / physiology

Substances

Insulin-Like Growth Factor Binding Proteins
Somatomedins
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II