Abstract
We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Azithromycin / pharmacology*
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Bacterial Proteins / drug effects*
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DNA-Binding Proteins / drug effects
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Lac Operon / drug effects
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Membrane Transport Proteins*
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Pseudomonas aeruginosa / drug effects*
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Trans-Activators / drug effects
Substances
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Anti-Bacterial Agents
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Bacterial Proteins
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DNA-Binding Proteins
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LasR protein, Pseudomonas aeruginosa
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Membrane Transport Proteins
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QsrP protein, Vibrio fischeri
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Trans-Activators
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xcpR protein, Pseudomonas aeruginosa
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Azithromycin