Abstract
The past decade produced several proposals for fine-scale gene mapping using linkage disequilibrium data. The suggested methods fall into two main groups, those that rely on pairwise statistics and those that rely on haplotypes. This paper reviews each strategy's development from a chronological perspective.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Alleles
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Biometry
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Chromosome Mapping / methods*
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Chromosome Mapping / statistics & numerical data
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Chromosome Mapping / trends
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Cystic Fibrosis / genetics
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Haplotypes
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Humans
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Likelihood Functions
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Linkage Disequilibrium*
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Models, Genetic
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Models, Statistical
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Mutation
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Recombination, Genetic