Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition

Bioorg Med Chem Lett. 2001 Apr 23;11(8):1019-22. doi: 10.1016/s0960-894x(01)00114-7.

Abstract

BM567, a sulfonylurea compound whose crystal structure is here discussed and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors. In this paper, their crystallographic and electronic structures are compared and lead to new synthesis prospects among the sulfonylurea series.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography
  • Hydrogen Bonding
  • Molecular Conformation
  • Molecular Structure
  • Pyridines / chemistry*
  • Pyridines / pharmacology*
  • Receptors, Thromboxane / antagonists & inhibitors*
  • Spectrophotometry, Atomic / methods
  • Static Electricity
  • Sulfonylurea Compounds / chemistry*
  • Sulfonylurea Compounds / pharmacology*
  • Thromboxane-A Synthase / antagonists & inhibitors*

Substances

  • BM 567
  • Pyridines
  • Receptors, Thromboxane
  • Sulfonylurea Compounds
  • terbogrel
  • Thromboxane-A Synthase