Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

H Iwasa; M Kurabayashi; R Nagai; Y Nakamura; T Tanaka

doi:10.1007/s100380170106

Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

J Hum Genet. 2001;46(3):158-62. doi: 10.1007/s100380170106.

Authors

H Iwasa¹, M Kurabayashi, R Nagai, Y Nakamura, T Tanaka

Affiliation

¹ Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Japan.

PMID: 11310586
DOI: 10.1007/s100380170106

Abstract

We report here 20 single-nucleotide polymorphisms (SNPs), including 15 novel ones, in six genes that are considered to be candidates for long QT syndrome (LQTS): 2 SNPs in KCNB1, 3 in KCND3, 3 in KCNJ11, 7 in ABCC9, 3 in ADRB1, and 2 in SLC18A2. We also examined their allelic frequencies in a Japanese sample population of LQTS-affected and nonaffected individuals. These data will be useful for genetic association studies designed to investigate acquired arrhythmias.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Arrhythmias, Cardiac / genetics
Base Sequence
Case-Control Studies
DNA Primers / genetics
Gene Frequency
Humans
Japan
Long QT Syndrome / genetics*
Polymorphism, Single Nucleotide*

Substances

DNA Primers