New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus

Z Naturforsch C J Biosci. 2001 Jan-Feb;56(1-2):49-52. doi: 10.1515/znc-2001-1-209.

Abstract

The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram(+), Gram(-) bacteria and pathogenic fungi.

MeSH terms

  • Anti-Bacterial Agents
  • Anti-Infective Agents / chemistry*
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Bacteria / drug effects*
  • Diterpenes / chemistry*
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology
  • Fungi / drug effects*
  • Greece
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Molecular Structure
  • Naphthols / chemistry
  • Rosales / chemistry*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Diterpenes
  • Naphthols
  • ent-8-hydroxylabda-13(16),14-diene